منابع مشابه
Expression of TGF-β3 in Isolated Fibroblasts from Foreskin
Background: The multifunctional transforming growth factor beta (TGF-β) is a glycoprotein that exists in three isoforms. TGF-β3 expression increases in fetal wound healing and reduces fibronectin and collagen I and III deposition, and also improves the architecture of the neodermis which is a combination of blood vessels and connective tissue during wound healing. Fibroblasts are key ...
متن کاملDiverse cellular TGF-β1 and TGF-β3 gene expression in normal human and murine lung
Diverse cellular TGF-β1 and TGF-β3 gene expression in normal human and murine lung. R.K. Coker, G.J. Laurent, S. Shahzeidi, N.A. Hernández-Rodríguez, P. Pantelidis, R.M. du Bois, P.K. Jeffery, R.J. McAnulty. ERS Journals Ltd 1996. ABSTRACT: A role for transforming growth factor-beta1 (TGF-β1) has been proposed in lung development and in the pathogenesis of pulmonary disease. However, previous ...
متن کاملTGF-β3 Inhibits Antibody Production by Human B Cells
TGF-β is a pleotropic cytokine involved in various biological processes. Of the three isoforms of TGF-β, TGF-β1 has long been recognized as an important inhibitory cytokine in the immune system and has been reported to inhibit B cell function in both mice and humans. Recently, it has been suggested that TGF-β3 may play an important role in the regulation of immune system in mice. Murine CD4+CD2...
متن کاملNeutralisation of TGF-β1 and TGF-β2 or exogenous addition of TGF-β3 to cutaneous rat wounds reduces scarring
Exogenous addition of neutralising antibody to transforming growth factor-β1,2 to cutaneous wounds in adult rodents reduces scarring. Three isoforms of transforming growth factor-β (1, 2 and 3) have been identified in mammals. We investigated the isoform/isoforms of TGF-β responsible for cutaneous scarring by: (i) reducing specific endogenous TGF-β isoforms by exogenous injection of isoform spe...
متن کاملexpression of tgf-β3 in isolated fibroblasts from foreskin
background: the multifunctional transforming growth factor beta (tgf-β) is a glycoprotein that exists in three isoforms. tgf-β3 expression increases in fetal wound healing and reduces fibronectin and collagen i and iii deposition, and also improves the architecture of the neodermis which is a combination of blood vessels and connective tissue during wound healing. fibroblasts are key cells in t...
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ژورنال
عنوان ژورنال: Cytokine & Growth Factor Reviews
سال: 2009
ISSN: 1359-6101
DOI: 10.1016/j.cytogfr.2009.07.002